The Cystine Knot Promotes Folding and Not Thermodynamic Stability in Vascular Endothelial Growth Factor
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چکیده
منابع مشابه
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor.
Cystine knots consist of three intertwined disulfide bridges and are considered major determinants of protein stability in proteins in which they occur. We questioned this function and observed that removal of individual disulfide bridges in human vascular endothelial growth factor (VEGF) does not reduce its thermodynamic stability but reduces its unexpected high thermal stability of 108 degree...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m206438200